See Also: Autosomal dominant hereditary spastic paraplegia(health)
spastic paraplegia, hereditary(medicine)
Autosomal dominant(health)
Autosomal dominant(medicine)
spastic paraplegia(medicine)
Autosomal dominant radial drusen(health)
kidney, polycystic, autosomal dominant(medicine)
congenital spastic paraplegia(medicine)
infantile spastic paraplegia(medicine)
Autosomal(medicine)

Autosomal dominant hereditary spastic paraplegia (health)


A degenerative disorder of nerves with progressive spasticity of the legs. Abbreviated as AD-HSP. Spasticity is a state of increased muscle tone. Paraplegia refers to the legs (quadriplegia refers to both the arms and legs). In hereditary spastic paraplegia there is an insidiously progressive condition characterized by weakness beginning in the feet and lower legs. There is stiffness of the legs in walking due to the spasticity. Autosomal dominant hereditary spastic paraplegia can result from changes in a number of different genes. Each gene is autosomal (on an nonsex chromosome) and dominant (capable of causing the disease by itself).