See Also: sickle cell disease(medicine)
Disease, sickle cell(health)
Sickle Cell Disease(health)
Sickle-cell disease(health)
sickle cell C disease(medicine)
sickle cell-thalassaemia disease(medicine)
sickle(dictionary)
Sickle(medicine)
sickle(dictionary)
hammer and sickle(dictionary)

Disease, sickle cell (health) and all out (iou)


Disease, sickle cell (health)


A genetic blood disease due to the presence of an abnormal form of hemoglobin, namely hemoglobin S. Hemoglobin is the molecule in red blood cells that transports oxygen from the lungs to the farthest reaches of the body. Sickle cell anemia is caused by an error in a gene that makes the beta globin chain of hemoglobin. The resultant abnormal hemoglobin (sickle hemoglobin) deforms the red blood cells when they are under low oxygen conditions. Children who inherit 2 copies of the sickle gene, one from each parent, have sickle cell anemia. Children who inherit the sickle gene from only one parent do not have the disease, but will carry the sickle cell trait. Individuals with sickle cell trait generally have no symptoms. The sickle mutation occurred thousands of years ago. The sickle gene became common in malarious areas because it affords a selective advantage against malaria. In sickle cell anemia, the hemoglobin molecules tend to aggregate after unloading oxygen. They form long, rod-like structures that force the red cells to assume a sickle shape. Unlike normal red cells, which are usually smooth and deformable, the sickle red cells cannot squeeze through small blood vessels.The sickle cells block little vessels depriving the organs of blood and oxygen. This leads to the periodic episodes of pain and damages the vital organs. Whereas normal red blood cells last about 120 days in the bloodstream, sickle red cells die after only about 10 to 20 days. Because they cannot be replaced fast enough, the blood is chronically short of red blood cells causing anemia -- sickle cell anemia.





all out (iou)



all out adverbial phr. & adjective. Also all-out. ME.
[from ALL adverb + OUT adverb.]
adverb. Entirely, completely, quite. Now arch. & dial. ME.
adverb & (with hyphen) adjective. To the fullest extent of someone or something's strength, power, resources, etc.; at full speed. L19.
E. F. Norton Irvine..was willing..to 'go all out', as he put it, in an utmost effort to reach the top. M. L. King The time has come for an all-out world war against poverty.