spine (iou) and shaggy kinase (medicine)

spine (iou)

spine noun. LME.
[Aphet. from Old French espine (mod. epine), or from its source Latin spina thorn, prickle, backbone, rel. to spica SPIKE noun2.]
I.
Botany. A stiff sharp-pointed outgrowth arising esp. from the wood of a plant; spec. one that represents a modified leaf, part of a leaf, or stipule. Cf. PRICKLE noun1 3, THORN noun 1. LME.
b. = NEEDLE noun 10. M19.
Anatomy. Any of several sharp-pointed slender processes of certain bones. E18.
Zoology. A stiff, pointed, thornlike process or appendage developed on the integument or shell of certain insects and Other invertebrates. E18.
b. Any of the prickles of a hedgehog, the quills of a porcupine, or similar growth on Other mammals. M18.
c. Any of the rigid, often sharp-pointed rays or spines in the fins of a fish. L18.
a. Any natural formation having a slender sharp-pointed form. M18.
b. A tall mass of lava projecting upwards from the mouth of a volcano. E20.
II.
The spinal column or backbone, freq. also including the spinal cord. LME.
Wilbur Smith Sean felt a cold wind blow down his spine.
transf. & fig. A part or formation having the function of a spine in a structure, object, etc.; a central feature, a main support; a source of strength. Also, strength of character, firmness. M17.
Tennyson The shock Of cataract seas that snap The three decker's oaken spine. Tucson Magazine No one cares or has the spine to sound off. Construction News Constructing a main spine with four spur blocks radiating east and west.
b. In full pay spine. A linear pay scale operated in some large bodies such as the civil service and allowing flexibility for local and specific conditions. L20.
The heartwood of a tree. M17.
A sharp ridge or projection of ground, rock, etc., esp. of a mountain range or hill. L18.
N. West He..climbed across the spine of the hill to look down on the Other side.
The part of a book's jacket or cover that encloses the back, usu. facing outwards on a shelf and bearing the title, author's name, etc. Also, the inner back of a book, the seam edge or glued edge of a book. E20.
R. Frame The gilt letters on the red spine of one of the..books. transf.: T. C. Boyle He..crossed the room to the stereo, ran a..finger along the spines of the albums.
Phrases: neural spine: see NEURAL adjective 1. RADIOLE spine. railway spine: see RAILWAY noun.
Comb.: spine-basher Austral. slang a loafer, an idler; spine-bashing Austral. slang idling, loafing; spinebill either of two small Australian honey-eaters of the genus Acanthorhynchus, which have long narrow down-curved bills; spine-chiller a thing or (occas.) person inspiring excitement and terror; esp. a horror or suspense story, Film, etc.; spine-chilling adjective (of a story, Film, etc.), inspiring excitement and terror, frightening; spinefoot any of several tropical marine fishes of the genus Siganus (family Siganidae), which bear several sharp venomous spines on the fins and occur in inshore waters of the Indo-Pacific; spine-freezer = spine-chiller above; spine-freezing adjective = spine-chilling above; spine-oak the heartwood of an oak; spine point each of the pay levels on a pay spine (see sense 6b above); spine road a major road linking Other important routes or points; spinetail any of various birds that have stiff, pointed tail feathers; esp. (a) any Central or S. American ovenbird of the subfamily Synallaxinae (family Furnariidae), inhabiting marshy areas and building complex covered nests; (b) = spine-tailed swift below; (c) Austral. a spine-tailed logrunner, Orthonyx temminckii; (d) N. Amer. = RUDDY duck; spine-tailed adjective having spinelike tail feathers; spine-tailed swift, any of various swifts of the tribe Chaeturini, which have the shafts of the tail feathers projecting beyond the tail; spine-tingler something thrilling or pleasurably frightening; esp. an exciting story etc.; a spine-chiller; spine-tingling adjective thrilling or pleasurably frightening, spine-chilling.
spined adjective (a) covered with spines, having spines of a specified kind or number; spinous, spiny;
spined loach, a common Eurasian loach, Cobitis taenia, which bears a backward-pointing spine below each eye; (b) having a spinal column: L18.
spinelike adjective resembling a spine M19.

shaggy kinase (medicine)

shaggy kinase
<enzyme> From drosophila; shares homology with mammalian glycogen synthase kinase 3; appears to be important for the normal seggregation of bristle precursor cells in the imaginal epithelium; can also function as negative regulators of jun-ap-1

Registry number: EC 2.7.1.-

Synonym: sgg kinase, shaggy gene product, sgg protein, zw3 protein, zw3 gene product, zeste-white 3 kinase, zeste-white 3

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