See Also: 5-oxoproline(medicine)
4-oxoproline reductase(medicine)
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5-oxoproline (medicine)


5-oxoproline


A keto derivative of proline that is formed nonenzymatically from glutamate, glutamine, and gamma-glutamylated peptides; it is also produced by the action of gamma-glutamylcyclotransferase; elevated levels of 5-oxoproline are often associated with problems of glutamine or glutathione metabolism.

Synonym: 5-pyrrolidone-2-carboxylic acid, pyroglutamic acid, pyrrolidone-5-carboxylate.