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Bcl-3 (medicine) and probabilify (iou)


Bcl-3 (medicine)


bcl-3 -->
bcl
<oncogene> Two variants of this oncogene are recognised.

1. Bcl-2: A proto-oncogene, activated by chromosome translocation in human B-cell lymphomas (hence bcl). Encodes a plasma membrane protein. The gene product inhibits programmed cell death (apoptosis) and is homologous with the worm gene ced 9.

See: ced mutant.

2. Bcl-3: An oncogene associated with some cases of B-cell chronic lymphocytic leukaemias. The protein product contains seven ankyrin repeats very similar to those found in I kappa B. Seems to interfere with binding of 50 kD subunit of NF kappa B to DNA.


probabilify (iou)



probabilify verb trans. M20.
[from PROBABILI(TY + -FY.]
Philosophy. Give probability to; give (a proposition) reasonable grounds for being true.
,probabilifi'cation noun M20.