See Also: Michaelis constant(medicine)
Michaelis constant(dictionary)
Michaelis-Menten constant(medicine)
Herbal medicine (botanical medicine, herbology, phytomedicine)(health)
Michaelis, Leonor(medicine)
Michaelis complex(medicine)
Michaelis-Menten hypothesis(medicine)
Michaelis-Menten equation(medicine)
Michaelis-Gutmann body(medicine)
Victor-Michaelis-Menten equation(medicine)

Michaelis constant (medicine)


Michaelis constant
<chemistry> The true dissociation constant for the enzyme-substrate binary complex in a single-substrate rapid equilibrium enzyme-catalyzed reaction (usually symbolised by Ks), the concentration of the substrate at which half the true maximum velocity of an enzyme-catalyzed reaction is achieved (when velocities are measured under initial rate and steady state conditions).

The ratio of rate constants (k2 + k3)/k1 in the single-substrate enzyme-catalyzed reaction: E + S &dblarr; ES &dblarr; E + products where E represents the free enzyme, S is the substrate, and ES is the central binary complex. The expression for the Michaelis constant will be more complex for multisubstrate reactions.

An apparent Michaelis constant is a constant determined either under conditions that are not strictly steady state and initial rate or one that varies with the concentration of one or more cosubstrates.

See: Michaelis-Menten equation.

Synonym: Michaelis-Menten constant.