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adrenaline reversal (medicine)


adrenaline reversal -->
epinephrine reversal


The fall in blood pressure produced by epinephrine when given following blockage of alpha-adrenergic receptors by an appropriate drug such as phenoxybenzamine; the vasodilation reflects the ability of epinephrine to activate beta-adrenergic receptors which, in vascular smooth muscle, are inhibitory; in the absence of alpha-receptor blockade, the beta-receptor activation by epinephrine is masked by its predominant action on vascular alpha-receptors, which causes vasoconstriction.

Synonym: adrenaline reversal.