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Saskatoon(tourism)
Saskatoon(encyclopedia)
saskatoon(dictionary)
Saskatoon airports(tourism)
Saskatoon flights(tourism)
Saskatoon doctors(health)
Saskatoon car rental(tourism)
Saskatoon City Hospital(health)
Saskatoon travel agency(tourism)

bretylium (medicine) and saskatoon (iou)


bretylium (medicine)


bretylium
<drug> An antihypertensive which on chronic oral dosing diminishes the release of norepinephrine from noradrenergic nerve endings.

Pharmacologic action: Suppress ventricular fibrillation and ventricular tachycardia, initially releases norepinephrine, then prevents synaptic release of norepinephrine; transiently increases myocardial contractilityUses: Treatment of refractory ventricular fibrillation and pulseless ventricular tachycardia after defibrillation, epinephrine, and lidocaine. Treatment of ventricular tachycardia with a pulse after lidocaine and procainamide. Treatment of wide complex tachycardia of uncertain type after lidocaine and adenosine.

Dose: 5 mg/kg IV initially, then 10 mg/kg every 5-10 minutes to a maximum of 30 mg/kg In persistently recurring ventricular tachycardia, load with 5-10 mg/kg diluted in 50 mL and infuse over 8-10 min. Follow with continuous infusion at 1-2 mg/min

Onset: Transient hypertension and tachycardia lasts about 20 min. Postural hypotension begins about 20 min after injection and peaks about 60 min later.

Potential complications: 1. May cause initial hypertension followed by a decrease in systemic vascular resistance and hypotension. 2. May exacerbate digitalis toxicityNote: Lidocaine is considered the first line drug for ventricular arrhythmias. Bretylium causes more hemodynamic instability than lidocaine and has not been shown to increase survival more than lidocaine.


saskatoon (iou)



saskatoon noun. Chiefly Canad. E19.
[Cree misa:skwato:min, from misa:skwat amelanchier + min berry.]
An amelanchier of western N. America, Amelanchier alnifolia; the sweet purple berry of this shrub.