trigonelline (medicine) and isocitric acid dehydrogenase (medicine)

trigonelline (medicine)

trigonelline

N-methylnicotinic acid;the methyl betaine of nicotinic acid; a product of the metabolism of nicotinic acid; excreted in the urine.

Synonym: caffearine, trigenolline.

isocitric acid dehydrogenase (medicine)

isocitric acid dehydrogenase -->
isocitrate dehydrogenase
<enzyme> An enzyme of the oxidoreductase class that catalyses the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires magnesium, mn2+; it is activated by ADP, citrate, and calcium, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle. (the NADP+ enzyme is EC 1.1.1.42.)

Chemical name: Isocitrate:NAD+ oxidoreductase (decarboxylating)

Registry number: EC 1.1.1.41

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