Constantine (sh) and gangliosidosis g(m1) (medicine)

Constantine (sh)

ancient Cirta

City (pop., 1998: 807,371), northeastern Algeria.

A natural fortress, it is situated on a rocky height some 800 ft (250 m) above the Rhumel River valley. By the 3rd century BC it was one of Numidia's most important towns, and it reached its apex of prosperity under Micipsa in the 2nd century BC. Ruined in subsequent wars, it was restored in AD 313 and renamed for its patron, the Roman emperor Constantine the Great. Overrun by the Arabs in the 7th century, it was ruled by a series of Arab and Berber dynasties and, intermittently, by the Ottoman Empire until it was captured by the French in 1837. Occupied in 1942 by U.S. troops, it was an important Allied staging area in World War II (1939-45). The city retains its medieval walls, and there are Roman ruins nearby. It is an agricultural market for the surrounding area.

gangliosidosis g(m1) (medicine)

gangliosidosis g(m1)

Form of gangliosidosis characterised by accumulation of g(m1) ganglioside and oligosaccharides, and caused by an absence or severe deficiency of beta-galactosidase a. The three phenotypes of g(m1) gangliosidosis are called infantile (generalised), juvenile, and adult (types 1, 2, and 3 respectively), referring to the age at which clinical manifestations appear.

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